🧠 Opus 4.5 just broke the charts

Good morning, AI enthusiast. Anthropic just dropped Opus 4.5, a faster, cheaper, more efficient frontier model that finally fixes Claude’s biggest pain point: short conversations that randomly cut off.

In today’s AI newsletter:

• Anthropic launches Opus 4.5

• US launches the genesis mission

• AI agent discovers 500+ age-reversing interventions

• How to change the camera angle of any image without losing detail

• AI tools & more

AI MODELS

🧠 Anthropic Launches Opus 4.5

Anthropic’s new Opus 4.5 boosts coding performance, improves memory in long chats, slashes token usage, and introduces a major price drop for developers. Claude will now summarize earlier messages instead of abruptly ending conversations, addressing one of users’ longest-running complaints.

• Claude now avoids hard-stop conversation cutoffs by auto-summarizing older messages

• Opus 4.5 hits 80.9% on SWE-Bench Verified, the first model to break 80%

• Outperforms GPT-5.1-Codex-Max (77.9%) and Gemini 3 Pro (76.2%) in coding and agentic tasks

• Massive price cut: Opus 4.5 API drops to $5/$25 per million tokens (from $15/$75)

• Uses up to 76% fewer output tokens compared to Sonnet 4.5 at similar performance

Opus 4.5 pushes Claude closer to true enterprise-scale usability. Longer coherent chats, cheaper tokens, stronger coding, and better security make this release a direct challenge to OpenAI’s GPT-5.1 and Google’s Gemini 3, and a major upgrade for devs building AI agents.

AI POLICY

🏛️ US Launches the Genesis Mission

The White House has unveiled the Genesis Mission, a Manhattan Project–style initiative to supercharge America’s AI, science, and energy capabilities. Built through the Department of Energy, the program connects national labs, supercomputers, scientific datasets, and autonomous robotic labs into one unified AI platform.

• DOE will build a national AI stack powered by U.S. supercomputers and federal science data

• New scientific foundation models across physics, materials, energy, bio, and climate

• AI agents + robotic labs will automate experiments in fusion, biotech, semiconductors, and advanced manufacturing

• DOE must identify 20 high-priority “national challenges” within 60 days to guide the mission’s roadmap

Genesis could rewire the US science and energy ecosystem, reducing reliance on private AI labs, accelerating breakthroughs in critical technologies, and creating a federal AI infrastructure to rival Big Tech’s platforms.

AI RESEARCH

🧬 AI Agent Discovers 500+ Age-Reversing Interventions

A new autonomous AI system called ClockBase Agent just reanalyzed millions of molecular datasets and uncovered age-modifying effects that thousands of researchers overlooked. By combining aging clocks with robotic hypothesis generation, the system mapped out what accelerates aging, and what actually reverses it.

• Analyzed nearly 2M human + mouse molecular profiles using 40+ aging clock models

• Ran 43,602 intervention-control comparisons and found 500+ interventions that reduce biological age

• Identified patterns across inflammation, metabolism, cardiac function, and neurobiology

• Experimental tests confirmed ouabain (a cardiac glycoside) improves frailty, inflammation, and heart function in aged mice

This could mark a turning point in longevity research. Instead of waiting years for individual studies, AI can now mine decades of unused data, generate hypotheses, and surface real age-reversing candidates, instantly accelerating the search for anti-aging therapies.

HOW TO AI

💻 How to Completely Shift the Camera Angle of Any Image

In this tutorial, you’ll learn how to completely shift the camera angle of any image using Qwen Image Edit, a powerful AI tool that lets you rotate, zoom, and pan your photo in 3D space, all without losing detail.

🧰 Who is This For

• Photographers who want to adjust framing without reshooting.

• 3D artists exploring new perspectives.

• Designers testing angles for product shots.

• Anyone curious about AI-powered camera control.

STEP 1: Access Qwen Image Edit

Head over to the Qwen Image Edit, Camera Angle Control page on Hugging Face Spaces.

Once there, you’ll see two main panels: Input Image and Output Image.

Click on “Click to Upload” or drag your photo into the input box.

STEP 2: Adjust Camera Controls

Below the image upload area, you’ll find three main sliders and one toggle:

Use the sliders to:

• Rotate your image left or right (up to ±90°).

• Move forward for a close-up or backward for a wide shot.

• Adjust vertical tilt from a bird’s-eye (top-down) to a worm’s-eye (low-angle) view.

If you want a broader field of view, toggle Wide-Angle Lens.

Once you’ve adjusted your settings, click “Generate” to process the image. Within seconds, you’ll see the new perspective rendered in the Output Image panel.

STEP 3: Explore Advanced Settings

If you want more precise control, open the Advanced Settings panel at the bottom of the interface. This section allows you to fine-tune how the AI interprets lighting, edges, and background reconstruction.

Here’s how you can use it effectively:

• Denoising Strength: Controls how much the AI modifies your image. A lower value keeps more original detail, while a higher value produces stronger transformations.

• Prompt Strength: Determines how closely the generation follows your prompt. If you’re combining text prompts (like “make it look cinematic”), increasing this value will help the AI better match your description.

• Seed: Lets you lock the randomness of results. Using the same seed with the same settings will recreate the same output.

• Sampling Steps: Defines how long the AI spends refining the image. More steps result in smoother and cleaner results but take slightly longer to generate.

These controls are perfect if you want a consistent aesthetic across multiple edits or are working on a series of angle variations from one source photo.

STEP 4: Generate and Compare Results

Once everything looks right, hit Generate.

Within seconds, Qwen will recreate your image from the new camera angle, maintaining lighting, depth, and proportions perfectly.

You can compare the before-and-after results in the Output Image panel and adjust again if needed.

OpenAI unveils a free shopping research feature in ChatGPT that delivers a personalized buyer's guide, powered by a custom version of GPT-5 mini.

Microsoft unveils Fara-7B, its first agentic SLM designed for computer use, available as an experimental release on Hugging Face and Microsoft Foundry.

Character.ai is cutting off access to ongoing chats for users under 18 over mental-health concerns, after adding a two-hour daily limit on October 29.

Google is starting to bridge OpenAI's product moat, like with Gemini's “dynamic view” option, which converts a text answer into an interactive, visual output.

🤖 Claude Opus 4.5: Anthropic’s new flagship model for coding, agents, and real computer use

🍌 Nano Banana 2: Google’s Gemini 3 image model with perfect text and character consistency

✨ Gemini 3: Google’s next-gen engine for multimodal reasoning

📖 NotebookLM: Lets you create clean infographics and slide decks using Nano Banana Pro

THAT’S IT FOR TODAY

Thanks for making it to the end! I put my heart into every email I send, I hope you are enjoying it. Let me know your thoughts so I can make the next one even better!

See you tomorrow :)

- Dr. Alvaro Cintas